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KMID : 0605620050120010062
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Journal of Korean Society of Biological Psychiatry
2005 Volume.12 No. 1 p.62 ~ p.67
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The CDH2 Gene Polymorphism in Schizophrenia
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Lee Won-Seok
Kim Mi-Kyung
Jung Han-Yong
Woo Sung-Il
Kwon Young-Jun
Kim Jong-Woo
Lee Hee-Jae
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Abstract
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Objectives: There has been increasing evidence that neurodevelopmental dysfunction is involved in the pathophysiology of schizophrenia. Cadherin is known to be one of the important molecules in neurodevelopment. This study was performed to examine the relationship between T816C polymorphism ofCDH2 gene and schizophrenia.
Methods: Genoytypes of T816C polymorphism of CDH2 gene were analyzed by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) in 156 Korea patents with schizophrenia and 170 controls.
Results: No difference was found between the patients with schizophrenia and the controls in genotype and allele frequencies of T816C polymorphism of CDH2 gene.
Conclusion: The results of this study do not support an association between T816C polymorphism of CDH2 gene and schizophrenia. However, it is necessary to investigate other polymorphic regions of CDH2 in schizophrenia.
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KEYWORD
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CDH2, Polymorphism, Schizophrenia
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